NIH is accepting proposals for 2010 NIH Director’s Pioneer Awards and New Innovator Awards. Both programs will support highly innovative, potentially high-impact approaches to major biomedical challenges. Pioneer Awardsprovide up to $2.5 million in direct costs over 5 years and are open to scientists at any career stage. New Innovator Awards provide up to $1.5 million in direct costs over the same period and are for early stage investigators (ESI) who have not received an NIH regular research (R01) or similar NIH grant. NIH expects to make at least 7 Pioneer Awards and at least 33 New Innovator Awards in September 2010.The deadline for submitting Pioneer Award applications is October 20, 2009. See the instructions in the RFA (RFA-RM-09-010) and http://nihroadmap.nih.gov/pioneer for more information. The deadline for submitting New Innovator Award applications is October 27, 2009. See the instructions in the RFA (RFA-RM-09-011) and http://nihroadmap.nih.gov/newinnovator for more information.